From OHC, Specialists in the Treatment of Adult Cancers and Blood Disorders

May 30, 2023

In the realm of cancer research, clinical trials stand as a beacon of hope, paving the way for new advancements and revolutionizing the way we approach cancer treatment. One innovative approach that has gained significant attention is the development of bi-specific T-cell engagers (BiTE), a groundbreaking therapeutic strategy that harnesses the power of the immune system to target and eliminate cancer cells. OHC is proud to bring this first-in-world technology to the Greater Cincinnati area.

How does BiTE work?

BiTE molecules are designed to bind simultaneously to T-cells and cancer cells, bringing them together. T-Cells are an important part of the human body’s immune defense. This enables T-cells to recognize cancer cells and initiate an immune response, leading to the destruction of the tumor.

OHC’s David M. Waterhouse, MD, MPH, medical oncologist, hematologist, and Director of Early Phase Clinical Trials, explains, “BiTEs function as molecular mediators, orchestrating a highly focused immune response against cancer cells. They provide a solution to the complex challenge of targeting tumors while minimizing damage to healthy tissues.”

Wide Range of Applications

One of the most promising aspects of BiTE therapy is its versatility. BiTEs have demonstrated efficacy across a variety of cancer types, including hematologic malignancies and solid tumors.

“By directing the patient’s own immune system to specifically target cancer cells, BiTEs hold immense potential in creating tailored treatments for a multitude of cancer types,” added Dr. Waterhouse.

Ongoing research and clinical trials are exploring the potential of BiTEs in treating breast cancer, lung cancer, and other challenging malignancies.

Unleashing the Power of Clinical Trials

Through these trials, innovative therapies like BiTE are put to the test, pushing the boundaries of what we thought was possible in cancer treatment. By participating, patients gain access to potentially life-saving therapies long before they are commercially available.

“Clinical trials provide a ray of hope for patients facing challenging circumstances. They inspire us to dream big and work tirelessly, knowing that every trial brings us one step closer to conquering cancer,” said Dr. Waterhouse. “Participating in a clinical trial should be the first step in cancer care, not simply the last.”

Beyond the Individual: Community Impact

Clinical trials extend their influence far beyond the individual patients who participate. They have a ripple effect on the community as a whole, driving progress and accelerating the pace of discovery.

“Clinical trials are transformative not only for patients but also for the broader community,” said Dr. Waterhouse. “They generate invaluable data that contributes to the collective understanding of cancer, benefiting countless lives.”

A Promising Horizon

The immense potential of BiTE therapy has sparked excitement and optimism among researchers and clinicians alike. Ongoing research aims to optimize BiTE molecules, refine their targeting capabilities, and minimize potential side effects.

OHC is presently offering BiTE clinical trials for diffuse large B-cell lymphoma, follicular lymphoma, metastatic prostate cancer, and small cell lung cancer.

These important trials not only provide hope for patients today but also lay the groundwork for future breakthroughs that will benefit generations to come. Together, we can embrace the power of clinical trials and pave the way for a world where cancer is overcome, one patient at a time.

To learn more about our cancer clinical trials program or to request a second opinion, call 1-888-649-4800 or visit

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